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Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. To determine whether the reduction of ER stress by these chaperones provided a functional benefit to the flies, we assessed the locomotor ability of GBA expressing flies fed with ambroxol or isofagomine for 10 days. Density of bands was determined using Image Lab software 5. How to cite this article : Sanchez-Martinez, A. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. See commentary " Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models " in Front Neurosci , volume 10,

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